Protective effect of hypoxylonol C and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin induced

Title
Protective effect of hypoxylonol C and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl isolated from Annulohypoxylon annulatum against streptozotocin induced
Authors
함정엽김태정김진철최필주김영석이다혜황병수송지훈박정식황귀서Noriko Yamabe강기성
Keywords
Annulohypoxylon annulatum; Pancreatic β-cells; Apoptosis; Streptozotocin
Issue Date
2019-09
Publisher
Bioorganic chemistry
Citation
VOL 90-103053-7
Abstract
We evaluated the protective effects of hypoxylonol C and 4,5,4′,5′-tetrahydroxy-1,1′-binaphthyl (BNT) isolated from Annulohypoxylon annulatum on pancreatic β-cell apoptosis, using the β-cell toxin streptozotocin (STZ). Hypoxylonol C and BNT restored the STZ-induced decrease in INS-1 cell viability in a dose-dependent manner. In addition, treatment of INS-1 cells with 50  μM STZ resulted in an increase in apoptotic cell death, which was observed as annexin V fluorescence intensity. Apoptotic cell death was decreased by co-treatment with 100  μM hypoxylonol C and 100  μM BNT. Similarly, STZ caused a marked increase in the expression of cleaved caspase-8, caspase-3, Bax, and poly (ADP-ribose) polymerase (PARP), as well as a decrease in the expression of B-cell lymphoma 2 (Bcl-2), which was reversed by co-treatment with 100  μM BNT. These findings suggest that hypoxylonol C and BNT play an important role in protecting pancreatic β-cells against apoptotic damage.
URI
http://pubs.kist.re.kr/handle/201004/69604
ISSN
0045-2068
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