Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T Cells

Title
Cell surface polysaccharides of Bifidobacterium bifidum induce the generation of Foxp3+ regulatory T Cells
Authors
이충구Ravi Verma이창헌전은지이재우김광순Ambarnil Ghosh변서현강혜지김기천전창덕Gwenael Jan서창희Jonathan SprentDipayan RudraCristina De CastroAntonio MolinaroCharles D. Surh임신혁Ju-Yang Jung
Issue Date
2018-10
Publisher
Science immunology
Citation
VOL 3, NO 28-eaat6975-15
Abstract
Dysregulation of intestinal microflora is linked to inflammatory disorders associated with compromised immunosuppressive functions of Foxp3(+) T regulatory (T-r(eg)) cells. Although mucosa-associated commensal microbiota has been implicated in T-reg generation, molecular identities of the "effector" components controlling this process remain largely unknown. Here, we have defined Bifidobacterium bifidum as a potent inducer of Foxp3(+) T-reg cells with diverse T cell receptor specificity to dietary antigens, commensal bacteria, and B. bifidum itself. Cell surface beta-glucan/galactan (CSGG) polysaccharides of B. bifidum were identified as key components responsible for T-reg induction. CSGG efficiently recapitulated the activity of whole bacteria and acted via regulatory dendritic cells through a partially Toll-like receptor 2-mediated mechanism. T-reg cells induced by B. bifidum or purified CSGG display stable and robust suppressive capacity toward experimental colitis. By identifying CSGG as a functional component of T-reg-inducing bacteria, our studies highlight the immunomodulatory potential of CSGG and CSGG-producing microbes.
URI
http://pubs.kist.re.kr/handle/201004/69607
ISSN
2470-9468
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