Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats
- Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats
- 윤인찬; 이지윤; 최혜영; 박찬솔; 장창영; 이경태; 이재열; 윤태영
- Lumbar spinal stenosis; Cauda equina; Neuropathic pain; Inflammation; Cyclooxygenase-2
- Issue Date
- International immunopharmacology
- VOL 75-105738-7
- Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrated macrophages, a key mediator of inflammation, in chronic neuropathic pain by LSS using an animal model. LSS was induced in adult male rats by cauda equina compression procedure using a silicone block within the epidural spaces of L5-L6 vertebrae. Locomotor deficit was observed after compression and mechanical allodynia was developed progressively for 4  weeks after injury. A number of macrophage were also infiltrated into the spinal parenchyma and cauda equina and COX-2 was expressed in infiltrated macrophages at 28  days after cauda equina compression. The administration of COX-2 inhibitors, celecoxib and MPO-0029, significantly alleviated LSS-induced chronic mechanical allodynia and inhibited the mRNA expression of inflammatory mediators such as tnf-α, Il-1β, il-6, and inos. Furthermore, COX-2 inhibitors significantly reduced prostaglandin E2 production. These results demonstrated the role of COX-2 in LSS-induced chronic neuropathic pain and suggest that the regulation of COX-2 can be considered as a therapeutic target to relive neuropathic pain.
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