Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats

Title
Inhibition of COX-2 alleviates lumbar spinal stenosis-induced chronic mechanical allodynia in rats
Authors
윤인찬이지윤최혜영박찬솔장창영이경태이재열윤태영
Keywords
Lumbar spinal stenosis; Cauda equina; Neuropathic pain; Inflammation; Cyclooxygenase-2
Issue Date
2019-10
Publisher
International immunopharmacology
Citation
VOL 75-105738-7
Abstract
Chronic low back pain due to lumbar spinal stenosis (LSS) is common, costly, mechanistically complex, and clinically challenging. However, the factors and mechanisms causing and mediating chronic pain induced by cauda equina compression remain unclear. Here, we examined the role of cyclooxygenase (COX)-2 in infiltrated macrophages, a key mediator of inflammation, in chronic neuropathic pain by LSS using an animal model. LSS was induced in adult male rats by cauda equina compression procedure using a silicone block within the epidural spaces of L5-L6 vertebrae. Locomotor deficit was observed after compression and mechanical allodynia was developed progressively for 4  weeks after injury. A number of macrophage were also infiltrated into the spinal parenchyma and cauda equina and COX-2 was expressed in infiltrated macrophages at 28  days after cauda equina compression. The administration of COX-2 inhibitors, celecoxib and MPO-0029, significantly alleviated LSS-induced chronic mechanical allodynia and inhibited the mRNA expression of inflammatory mediators such as tnf-α, Il-1β, il-6, and inos. Furthermore, COX-2 inhibitors significantly reduced prostaglandin E2 production. These results demonstrated the role of COX-2 in LSS-induced chronic neuropathic pain and suggest that the regulation of COX-2 can be considered as a therapeutic target to relive neuropathic pain.
URI
http://pubs.kist.re.kr/handle/201004/69631
ISSN
1567-5769
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KIST Publication > Article
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