Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation

Title
Obovatol inhibits NLRP3, AIM2, and non-canonical inflammasome activation
Authors
김진철김정은안희정한병철신현정정의만김주열양희정이정현강승구이승호이근식
Issue Date
2019-10
Publisher
Phytomedicine : international journal of phytotherapy and phytopharmacology
Citation
VOL 63-153019-9
Abstract
Background Obovatol, a biphenolic chemical originating from Magnolia obovata, has been utilized as a traditional medicine for the treatment of inflammatory diseases. Inflammasome induces maturation of inflammatory cytokines in response to intracellular danger signals, and its dysregulation induces inflammatory diseases. Purpose The effect of obovatol on inflammasome activation has not been reported, although its anti-inflammatory properties have been studied. Study design/methods Obovatol was treated to macrophages with inflammasome triggers, and secretions of interleukin (IL)-1β, IL-18, and caspase-1 were measured as readouts of inflammasome activation. In addition, Asc pyroptosome formation, caspase-1 activity, and mitochondrial reactive oxygen species (ROS) production were analyzed in mechanical studies. Anti-inflammasome properties of obovatol were confirmed in an animal model. Results Obovatol inhibited NLRP3, AIM2, and non-canonical inflammasomes through inhibition of Asc pyroptosome formation and mitochondrial ROS generation. In addition, obovatol disrupted the priming step of inflammasome activation and inhibited transcription of inflammatory cytokines. In mice, obovatol attenuated serum IL-1β elevation in response to monosodium urate crystals. Conclusion Obovatol is suggested as an inhibitor of NLRP3, AIM2, and non-canonical inflammasomes.
URI
http://pubs.kist.re.kr/handle/201004/69708
ISSN
0944-7113
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE