Photoacoustic imaging of cancer cells with glycol-chitosan-coated gold nanoparticles as contrast agents

Title
Photoacoustic imaging of cancer cells with glycol-chitosan-coated gold nanoparticles as contrast agents
Authors
김광명선인철안철희Emelianov, Stanislav
Issue Date
2019-12
Publisher
Journal of biomedical optics
Citation
VOL 24, NO 12-121903-5
Abstract
Utility of glycol-chitosan-coated gold nanoparticles (GC-AuNPs) as a photoacoustic contrast agent for cancer cell imaging was demonstrated. Through the synergistic effect of glycol chitosan and gold nanoparticles, GC-AuNPs showed cellular uptake in breast cancer cells and resulted in strong photoacoustic signals in tissue-mimicking cell phantoms. The performance of GC-AuNPs as contrast agents was established with photoacoustic imaging and confirmed with dark-field microscopy. The cell phantoms displayed strong photoacoustic signals if cells were incubated more than 3 h with GC-AuNPs, compared with PEG-AuNPs that showed no photoacoustic signal increase. The enhanced photoacoustic signals originated from the plasmon coupling effect of GC-AuNPs after the cellular uptake in cancer cells. Importantly, photoacoustic imaging of cancer cells was achieved with GC-AuNPs— contrast agents that did not require antibodies or complex surface modification. The endocytosis of GC-AuNPs was also confirmed with dark-field microscopy. The results show that GC-AuNPs have potential as a photoacoustic contrast agent for cellular imaging including tumor tissue imaging.
URI
http://pubs.kist.re.kr/handle/201004/69747
ISSN
1083-3668
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KIST Publication > Article
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