Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference

Title
Activation of Astrocytic μ-Opioid Receptor Causes Conditioned Place Preference
Authors
박기덕남민호이승은이재광우준성전희정원우진한경석고우현배진영김재영Elliot Kwong최태용김상범최세영배용철이창준
Keywords
Astrocyte; Mu-opioid receptor; Hippocampus; Conditioned place preference; LTP
Issue Date
2019-07
Publisher
Cell Reports
Citation
VOL 28-1166
Abstract
The underlying mechanisms of how positive emotional valence (e.g., pleasure) causes preference of an associated context is poorly understood. Here, we show that activation of astrocytic μ-opioid receptor (MOR) drives conditioned place preference (CPP) by means of specific modulation of astrocytic MOR, an exemplar endogenous Gi protein-coupled receptor (Gi-GPCR), in the CA1 hippocampus. Long-term potentiation (LTP) induced by a subthreshold stimulation with the activation of astrocytic MOR at the Schaffer collateral pathway accounts for the memory acquisition to induce CPP. This astrocytic MOR-mediated LTP induction is dependent on astrocytic glutamate released upon activation of the astrocytic MOR and the consequent activation of the presynaptic mGluR1. The astrocytic MOR-dependent LTP and CPP were recapitulated by a chemogenetic activation of astrocyte-specifically expressed Gi-DREADD hM4Di. Our study reveals that the transduction of inhibitory Gi-signaling into augmented excitatory synaptic transmission through astrocytic glutamate is critical for the acquisition of contextual memory for CPP.
URI
http://pubs.kist.re.kr/handle/201004/69770
ISSN
2211-1247
Appears in Collections:
KIST Publication > Article
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