Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE(2) and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages

Title
Synthesis of New Triarylpyrazole Derivatives Possessing Terminal Sulfonamide Moiety and Their Inhibitory Effects on PGE(2) and Nitric Oxide Productions in Lipopolysaccharide-Induced RAW 264.7 Macrophages
Authors
유경호오창현Mohammed S. Abdel-MaksoudMohammed I. El-GamalMahmoud M. Gamal El-DinYunji ChoiJungseung ChoiJi-Sun ShinShin-Young KangKyung-Tae LeeDaejin Baek
Issue Date
2018-10
Publisher
Molecules
Citation
VOL 23, NO 10-20
Abstract
This article describes the design, synthesis, and in vitro anti-inflammatory screening of new triarylpyrazole derivatives. A total of 34 new compounds were synthesized containing a terminal arylsulfonamide moiety and a different linker between the sulfonamide and pyridine ring at position 4 of the pyrazole ring. All the target compounds were tested for both cytotoxicity and nitric oxide (NO) production inhibition in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages. Compounds 1b, 1d, 1g, 2a, and 2c showed the highest NO inhibition percentages and the lowest cytotoxic effect. The most potent derivatives were tested for their ability to inhibit prostaglandin E2 (PGE2) in LPS-induced RAW 264.7 macrophages. The IC50 for nitric oxide inhibition, PGE2 inhibition, and cell viability were determined. In addition, 1b, 1d, 1g, 2a, and 2c were tested for their inhibitory effect on LPS-induced inducible nitric oxide synthase (iNOS) and Cyclooxygenase 2 (COX-2) protein expression as well as iNOS enzymatic activity.
URI
http://pubs.kist.re.kr/handle/201004/69787
ISSN
1420-3049
Appears in Collections:
KIST Publication > Article
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