Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device

Title
Automated Dielectrophoretic Tweezers-Based Force Spectroscopy System in a Microfluidic Device
Authors
이상엽남기환Min Hyung KimJeongjick LeeIn Soo ParkMyeonggu SonHyunchul KoDae Sung YoonWoo-Jin ChangSei Young LeeYoung Ro YoonSang Woo Lee
Issue Date
2017-10
Publisher
Sensors
Citation
VOL 17, NO 10-9
Abstract
We reported an automated dielectrophoretic (DEP) tweezers-based force spectroscopy system to examine intermolecular weak binding interactions, which consists of three components: (1) interdigitated electrodes and micro-sized polystyrene particles used as DEP tweezers and probes inside a microfluidic device, along with an arbitrary function generator connected to a high voltage amplifier; (2) microscopy hooked up to a high-speed charge coupled device (CCD) camera with an image acquisition device; and (3) a computer aid control system based on the LabVIEW program. Using this automated system, we verified the measurement reliability by measuring intermolecular weak binding interactions, such as hydrogen bonds and Van der Waals interactions. In addition, we also observed the linearity of the force loading rates, which is applied to the probes by the DEP tweezers, by varying the number of voltage increment steps and thus affecting the linearity of the force loading rates. This system provides a simple and low-cost platform to investigate intermolecular weak binding interactions.
URI
http://pubs.kist.re.kr/handle/201004/69812
ISSN
1424-8220
Appears in Collections:
KIST Publication > Article
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