Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo
- Multifunctional multi-shank neural probe for investigating and modulating long-range neural circuits in vivo
- 우지완; 조일주; 최낙원; 조약돌; 손유진; 채의규; 신효근; 김정연; 이현주; 양수현; 이창준
- Issue Date
- Nature Communications
- VOL 10, NO 1-11
- Investigation and modulation of neural circuits in vivo at the cellular level are very important
for studying functional connectivity in a brain. Recently, neural probes with stimulation capabilities have been introduced, and they provided an opportunity for studying neural activities at a specific region in the brain using various stimuli. However, previous methods have a limitation in dissecting long-range neural circuits due to inherent limitations on their designs. Moreover, the large size of the previously reported probes induces more significant tissue damage. Herein, we present a multifunctional multi-shank MEMS neural probe that is monolithically integrated with an optical waveguide for optical stimulation, microfluidic channels for drug delivery, and microelectrode arrays for recording neural signals from different regions at the cellular level. In this work, we successfully demonstrated the functionality of our probe by confirming and modulating the functional connectivity between the hippocampal CA3 and CA1 regions in vivo.
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