Simultaneous transrectal ultrasound and photoacoustic human prostate imaging

Title
Simultaneous transrectal ultrasound and photoacoustic human prostate imaging
Authors
이병철Sri-Rajasekhar KothapalliGeoffrey A. SonnJung Woo ChoeAmin NikoozadehAnshuman BhuyanKwan Kyu ParkPaul CristmanRichard FanAzadeh MoiniJonathan WuThomas E. CarverDharati TrivediLillian ShiibaIdan SteinbergDavid M. HulandMorten F. RasmussenJoseph C. LiaoJames D. BrooksPierre T. Khuri-YakubSanjiv S. Gambhir
Issue Date
2019-08
Publisher
Science Translational Medicine
Citation
VOL 11-12
Abstract
Imaging technologies that simultaneously provide anatomical, functional, and molecular information are emerging as an attractive choice for disease screening and management. Since the 1980s, transrectal ultrasound (TRUS) has been routinely used to visualize prostatic anatomy and guide needle biopsy, despite limited specificity. Photoacoustic imaging (PAI) provides functional and molecular information at ultrasonic resolution based on optical absorption. Combining the strengths of TRUS and PAI approaches, we report the development and bench-to-bedside translation of an integrated TRUS and photoacoustic (TRUSPA) device. TRUSPA uses a miniaturized capacitive micromachined ultrasonic transducer array for simultaneous imaging of anatomical and molecular optical contrasts [intrinsic: hemoglobin; extrinsic: intravenous indocyanine green (ICG)] of the human prostate. Hemoglobin absorption mapped vascularity of the prostate and surroundings, whereas ICG absorption enhanced the intraprostatic photoacoustic contrast. Future work using the TRUSPA device for biomarker-specific molecular imaging may enable a fundamentally new approach to prostate cancer diagnosis, prognostication, and therapeutic monitoring.
URI
http://pubs.kist.re.kr/handle/201004/69860
ISSN
1946-6234
Appears in Collections:
KIST Publication > Article
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