Gas-generating nanoparticles for contrastenhanced ultrasound imaging

Title
Gas-generating nanoparticles for contrastenhanced ultrasound imaging
Authors
선인철Stanislav Emelianov
Keywords
gold nanoparticle; ultrasound imaging; gas bubble generation
Issue Date
2019-09
Publisher
Nanoscale
Citation
VOL 11-16240
Abstract
We present gas-generating solid nanoparticles as a new concept of an ultrasound contrast agent. The developed nanoparticles are sufficiently small (less than 100 nm in diameter) to escape vasculature and yet, upon external pulsed laser light activation, release nitrogen gas for enhanced contrast in ultrasound imaging. The gas-generating nanoconstructs combine the photocatalytic function of gold nanoparticles and photolysis of azide compounds. Using ultrasound imaging, we demonstrate the controlled, on-demand generation of nitrogen gas from nanoparticles due to the decomposition of azide groups triggered by pulsed laser irradiation. The resulting gas forms bubbles that cause backscattered ultrasound signals and, therefore, modulate the contrast in ultrasound imaging.
URI
http://pubs.kist.re.kr/handle/201004/69898
ISSN
2040-3364
Appears in Collections:
KIST Publication > Article
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