Integrating Organs-on-a-chips: multiplexing, scaling, vascularization, and innervation

Title
Integrating Organs-on-a-chips: multiplexing, scaling, vascularization, and innervation
Authors
김수현정영미정지홍이재서박도연
Issue Date
2020-01
Publisher
Trends in biotechnology
Citation
VOL 38, NO 1-112
Abstract
Organs-on-chips (OoCs) have attracted significant attention because they can be designed to mimic in vivo environments. Beyond constructing a single OoC, recent efforts have tried to integrate multiple OoCs to broaden potential applications such as disease modeling and drug discoveries. However, various challenges remain for integrating OoCs towards in vivo-like operation, such as incorporating various connections for integrating multiple OoCs. We review multiplexed OoCs and challenges they face: scaling, vascularization, and innervation. In our opinion, future OoCs will be constructed to have increased predictive power for in vivo phenomena and will ultimately become a mainstream tool for high quality biomedical and pharmaceutical research.
URI
http://pubs.kist.re.kr/handle/201004/69900
ISSN
0167-7799
Appears in Collections:
KIST Publication > Article
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