Experimental and Theoretical Structural Characterization of Cu?Au Tripods for Photothermal Anticancer Therapy

Title
Experimental and Theoretical Structural Characterization of Cu?Au Tripods for Photothermal Anticancer Therapy
Authors
이재갑김광명Kailash Pati Shiva Sankar HembramSubramanian Tamil Selvan이동기Sitansu Sekhar Nanda
Issue Date
2019-06
Publisher
ACS applied nano materials
Citation
VOL 2, NO 6-3742
Abstract
Anisotropic metal nanostructures (e.g., Au&#8211; Ag, Au&#8211; Cu) are emerging for biomedical and catalytic applications in recent years. Herein, we report a modified synthesis of Cu&#8211; Au tripod nanocrystals through the controlled nucleation and growth process with judicious purification for photothermal based anticancer therapy. The distribution of nanocrystals in tripod was analyzed by STEM-EDX mapping, indicating the formation of Cu&#8211; Au alloy nanocrystals. Theoretical calculations showed the possible formation of alloy structures, that is, Cu3Au, Cu&#8211; Au, and CuAu3 and confirmed that their stability in the following order: CuAu3 < Cu&#8211; Au < Cu3Au. These stable tripods exhibited a well pronounced photothermal effect as demonstrated by experimental and simulation photothermal studies. Cancer cells treated with nanocrystals upon NIR laser exposure showed promising therapeutic effects.
URI
http://pubs.kist.re.kr/handle/201004/69953
ISSN
2574-0970
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KIST Publication > Article
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