Synthetic anion transporters as endoplasmic reticulum (ER) stress inducers

Title
Synthetic anion transporters as endoplasmic reticulum (ER) stress inducers
Authors
바스카Adil S. AslamAhmed Fuwad류현일송재원김대원김선민전태준조동규이재욱
Issue Date
2019-10
Publisher
Organic letters
Citation
VOL 21, NO 19-7832
Abstract
Cl− -ion transporters (2a− 2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl− -ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP.
URI
http://pubs.kist.re.kr/handle/201004/69968
ISSN
1523-7060
Appears in Collections:
KIST Publication > Article
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