Synthetic anion transporters as endoplasmic reticulum (ER) stress inducers
- Synthetic anion transporters as endoplasmic reticulum (ER) stress inducers
- 바스카; Adil S. Aslam; Ahmed Fuwad; 류현일; 송재원; 김대원; 김선민; 전태준; 조동규; 이재욱
- Issue Date
- Organic letters
- VOL 21, NO 19-7832
- Cl− -ion transporters (2a− 2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl− -ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved
forms of Caspase 3 and PARP.
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