Distribution of polyamines may be altered in differnet scalp regions of patients with hairloss
- Distribution of polyamines may be altered in differnet scalp regions of patients with hairloss
- 이정애; 정봉철; 이유라; 유박린; 심우영; 홍종기
- polyamine; scalp region; hairloss; HPLC/MS
- Issue Date
- Experimental dermatology
- VOL 28-1085
- Hair loss, from the vertex or front of the head, generally occurs due to increased androgenic steroid levels. Androgenic steroids, particularly testosterone and dihydrotestosterone, are distributed differently across the vertex and occipital regions and are involved in inducing ornithine decarboxylase expression. Therefore, we hypothesized that the distribution of polyamines may be altered in different scalp regions. For the overall metabolic profiling of polyamines in
patients with hair loss, a liquid chromatography‐ mass spectrometry was used. We investigated the differential polyamine levels in different regions of the hair of patients with male pattern baldness and those with female pattern hair loss. The levels of most polyamines were higher in the vertex region than in the occipital region, and N‐ acetyl polyamine levels differed significantly. We proposed to test our hypothesis by profiling polyamines in human hair fibre to evaluate the distribution of metabolites in various regions of the scalp.
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