Distribution of polyamines may be altered in differnet scalp regions of patients with hairloss

Title
Distribution of polyamines may be altered in differnet scalp regions of patients with hairloss
Authors
이정애정봉철이유라유박린심우영홍종기
Keywords
polyamine; scalp region; hairloss; HPLC/MS
Issue Date
2019-06
Publisher
Experimental dermatology
Citation
VOL 28-1085
Abstract
Hair loss, from the vertex or front of the head, generally occurs due to increased androgenic steroid levels. Androgenic steroids, particularly testosterone and dihydrotestosterone, are distributed differently across the vertex and occipital regions and are involved in inducing ornithine decarboxylase expression. Therefore, we hypothesized that the distribution of polyamines may be altered in different scalp regions. For the overall metabolic profiling of polyamines in patients with hair loss, a liquid chromatography‐ mass spectrometry was used. We investigated the differential polyamine levels in different regions of the hair of patients with male pattern baldness and those with female pattern hair loss. The levels of most polyamines were higher in the vertex region than in the occipital region, and N‐ acetyl polyamine levels differed significantly. We proposed to test our hypothesis by profiling polyamines in human hair fibre to evaluate the distribution of metabolites in various regions of the scalp.
URI
http://pubs.kist.re.kr/handle/201004/69978
ISSN
0906-6705
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE