Altered polyamines profiling in the hair of patients with androgenetic alopecia and alopecia areata

Title
Altered polyamines profiling in the hair of patients with androgenetic alopecia and alopecia areata
Authors
이정애정봉철이유라유박린심우영홍종기
Keywords
alopecia areata; androgenetic alopecia; autoimmune disease; hair folicle; polyamine
Issue Date
2019-11
Publisher
The Journal of dermatology
Citation
VOL 46, NO 11-992
Abstract
Hair follicles are among the most highly proliferative tissues. Polyamines are associated with proliferation, and several polyamines including spermidine and spermine play anti-inflammatory roles. Androgenic alopecia results from increased dihydrotestosterone metabolism, and alopecia areata is an autoimmune disease. This study aimed to investigate differences in polyamine profiles in hair samples between patients with androgenic alopecia and alopecia areata. Polyamine concentrations were determined through high-performance liquid chromatography– mass spectrometry. Hair samples were derivatized with isobutyl chloroformate. Differences in polyamine levels were observed between androgenic alopecia and alopecia areata compared with normal controls. In particular, polyamine levels were higher in alopecia areata patients than in normal controls. Certain polyamines displayed different concentrations between the androgenic alopecia and alopecia areata groups, suggesting that some polyamines, particularly N-acetyl putrescine (P = 0.007) and N-acetyl cadaverine (P = 0.0021), are significantly different in androgenic alopecia. Furthermore, spermidine (P = 0.021) was significantly different in alopecia areata. Our findings suggest that non-invasive quantification of hair polyamines may help distinguish between androgenic alopecia and alopecia areata. Our study provides novel insights into physiological alterations in patients with androgenic alopecia and those with alopecia areata and reveals some differences in polyamine levels in hair loss diseases with two different modes of action.
URI
http://pubs.kist.re.kr/handle/201004/69979
ISSN
0385-2407
Appears in Collections:
KIST Publication > Article
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