Justicidin Areduces b-amyloid via inhibiting endocytosis of b-amyloid precursor protein

Title
Justicidin Areduces b-amyloid via inhibiting endocytosis of b-amyloid precursor protein
Authors
양현옥Oh-Hoon Kwon천윤선Hyun Geun OhYoon Young ChoSungkwon Chung
Issue Date
2019-03
Publisher
Biomolecules & Therapeutics
Citation
VOL 27, NO 3-282
Abstract
β-amyloid precursor protein (APP) can be cleaved by α-, and γ-secretase at plasma membrane producing soluble ectodomain fragment (sAPPα). Alternatively, following endocytosis, APP is cleaved by β-, and γ-secretase at early endosomes generating β-amyloid (Aβ), the main culprit in Alzheimer’s disease (AD). Thus, APP endocytosis is critical for Aβ production. Recently, we reported that Monsonia angustifolia, the indigenous vegetables consumed in Tanzania, improved cognitive function and decreased Aβ production. In this study, we examined the underlying mechanism of justicidin A, the active compound of M. angustifolia, on Aβ production. We found that justicidin A reduced endocytosis of APP, increasing sAPPα level, while decreasing Aβ level in HeLa cells overexpressing human APP with the Swedish mutation. The effect of justicidin A on Aβ production was blocked by endocytosis inhibitors, indicating that the decreased APP endocytosis by justicidin A is the underlying mechanism. Thus, justicidin A, the active compound of M. angustifolia, may be a novel agent for AD treatment.
URI
http://pubs.kist.re.kr/handle/201004/70001
ISSN
1976-9148
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KIST Publication > Article
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