Anti-neuroinflammatory effects of 12-dehydrogingerdione in LPS-activated microglia through inhibiting Akt/IKK /NF-κB pathway and activating Nrf-2/HO-1 pathway

Title
Anti-neuroinflammatory effects of 12-dehydrogingerdione in LPS-activated microglia through inhibiting Akt/IKK /NF-κB pathway and activating Nrf-2/HO-1 pathway
Authors
양현옥조동장리준구밍야오서구량류시용
Issue Date
2019-01
Publisher
Biomolecules & Therapeutics
Citation
VOL 27, NO 1-100
Abstract
Ginger, one of worldwide consumed dietary spice, is not only famous as food supplements, but also believed to exert a variety of remarkable pharmacological activity as herbal remedies. In this study, a ginger constituent, 12-dehydrogingerdione (DHGD) was proven that has comparable anti-inflammatory activity with positive control 6-shogaol in inhibiting LPS-induced interleukin (IL)-6, tumor necrosis factor (TNF)-α, prostaglandin (PG) E2, nitric oxide (NO), inducible NO synthase (iNOS) and cyclooxygenase (COX)-2, without interfering with COX-1 in cultured microglial cells. Subsequent mechanistic studies indicate that 12-DHGD may inhibit neuro-inflammation through suppressing the LPS-activated Akt/IKK/NF-κB pathway. Furthermore, 12-DHGD markedly promoted the activation of NF-E2-related factor (Nrf)-2 and heme oxygenase (HO)-1, and we demonstrated that the involvement of HO-1 on the production of pro-inflammatory mediators such as NO and TNF-α by using a HO-1 inhibitor, Zinc protoporphyrin (Znpp). These results indicate that 12-DHGD may protect against neuro-inflammation by inhibiting Akt/IKK/IκB/NF-κB pathway and promoting Nrf-2/HO-1 pathway.
URI
http://pubs.kist.re.kr/handle/201004/70002
ISSN
1976-9148
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE