A Novel Blood-Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein-2

Title
A Novel Blood-Based Colorectal Cancer Diagnostic Technology Using Electrical Detection of Colon Cancer Secreted Protein-2
Authors
이관희전민홍최재원박성욱이효정도은주성유나홍승모김상엽김동희강자영손혜남주진명송은미황성욱박상형양동훈예병덕변정식채재원양석균Helen MoinovaSanford D. Markowitz명승재
Keywords
electric­field effect colorectal sensor; colon cancer secreted protein­2; colorectal cancer
Issue Date
2019-06
Publisher
Advanced science
Citation
VOL 6, NO 11-1802115-10
Abstract
Colorectal cancer (CRC) is the second&#8208; leading cause of cancer&#8208; related mortality worldwide, which may be effectively reduced by early screening. Colon cancer secreted protein&#8208; 2 (CCSP&#8208; 2) is a promising blood marker for CRC. An electric&#8208; field effect colorectal sensor (E&#8208; FECS), an ion&#8208; sensitive field&#8208; effect transistor under dual gate operation with nanostructure is developed, to quantify CCSP&#8208; 2 directly from patient blood samples. The sensing performance of the E&#8208; FECS is verified in 7 controls and 7 CRC samples, and it is clinically validated on 30 controls, 30 advanced adenomas, and 81 CRC cases. The concentration of CCSP&#8208; 2 is significantly higher in plasma samples from CRC and advanced adenoma compared with controls (both P < 0.001). Sensitivity and specificity for CRC versus controls are 44.4% and 86.7%, respectively (AUC of 0.67), and 43.3% and 86.7%, respectively, for advanced adenomas (AUC of 0.67). CCSP&#8208; 2 detects a greater number of CRC cases than carcinoembryonic antigen does (45.6% vs 24.1%), and the combination of the two markers detects an even greater number of cases (53.2%). The E&#8208; FECS system successfully detects CCSP&#8208; 2 in a wide range of samples including early stage cancers and advanced adenoma. CCSP&#8208; 2 has potential for use as a blood&#8208; based biomarker for CRC.
URI
http://pubs.kist.re.kr/handle/201004/70043
ISSN
2198-3844
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KIST Publication > Article
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