Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau

Title
Pan-HDAC Inhibitors Promote Tau Aggregation by Increasing the Level of Acetylated Tau
Authors
이수현이준석김윤경임성수신슬기정현정백자현
Keywords
histone deacetylase inhibitor; tau acetylation; tau aggregation; Alzheimer's disease
Issue Date
2019-09
Publisher
International journal of molecular sciences
Citation
VOL 20-4283-12
Abstract
Epigenetic remodeling via histone acetylation has become a popular therapeutic strategy to treat Alzheimer’s disease (AD). In particular, histone deacetylase (HDAC) inhibitors including M344 and SAHA have been elucidated to be new drug candidates for AD, improving cognitive abilities impaired in AD mouse models. Although emerged as a promising target for AD, most of the HDAC inhibitors are poorly selective and could cause unwanted side e ects. Here we show that tau is one of the cytosolic substrates of HDAC and the treatment of HDAC inhibitors such as Scriptaid, M344, BML281, and SAHA could increase the level of acetylated tau, resulting in the activation of tau pathology.
URI
http://pubs.kist.re.kr/handle/201004/70104
ISSN
1422-0067
Appears in Collections:
KIST Publication > Article
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