Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules

Title
Downregulation of lipopolysaccharide response in Drosophila by negative crosstalk between the AP1 and NF-kappaB signaling modules
Authors
이욱빈Taeil KimJoonsun YoonHwansung ChoJoon KimYoung-Hwa SongSe Nyun KimJeong Ho YoonJeongsil Kim-HaYoung-Joon Kim
Issue Date
2005-02
Publisher
Nature immunology
Citation
VOL 6, NO 2-218
Abstract
IkappaB kinase (IKK) and Jun N-terminal kinase (Jnk) signaling modules are important in the synthesis of immune effector molecules during innate immune responses against lipopolysaccharide and peptidoglycan. However, the regulatory mechanisms required for specificity and termination of these immune responses are unclear. We show here that crosstalk occurred between the drosophila Jnk and IKK pathways, which led to downregulation of each other's activity. The inhibitory action of Jnk was mediated by binding of drosophila activator protein 1 (AP1) to promoters activated by the transcription factor NF-kappaB. This binding led to recruitment of the histone deacetylase dHDAC1 to the promoter of the gene encoding the antibacterial protein Attacin-A and to local modification of histone acetylation content. Thus, AP1 acts as a repressor by recruiting the deacetylase complex to terminate activation of a group of NF-kappaB target genes.
URI
http://pubs.kist.re.kr/handle/201004/70222
ISSN
1529-2908
Appears in Collections:
KIST Publication > Article
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