Phenotype-based discovery of a HeLa-specific Cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage

Title
Phenotype-based discovery of a HeLa-specific Cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage
Authors
이상희백수연조완상홍성렬이시형김희준박한검정진주신영기박승범
Issue Date
2019-08
Publisher
Organic & biomolecular chemistry
Citation
VOL 17, NO 31-7397
Abstract
Selective bioactive compounds have emerged as major players in chemical biology for their potential in disrupting diverse biological pathways with minimal adverse effects. Using phenotypic screening, we identified an anti-cancer agent, SB2001, with a highly specific cytotoxicity toward HeLa human cervical cancer cells. The subsequent mechanistic study revealed that SB2001 induced apoptotic cell death through restoring p53 function and suppressed the human papillomavirus (HPV)-mediated oncoprotein signaling pathway via oxidative damage in HeLa cells. SB2001 also selectively induced HeLa-specific tumor regression without any adverse effects in an in vivo tumor xenograft model, demonstrating its potential as a promising chemical probe.
URI
http://pubs.kist.re.kr/handle/201004/70240
ISSN
1477-0520
Appears in Collections:
KIST Publication > Article
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