Phenotype-based discovery of a HeLa-specific Cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage
- Phenotype-based discovery of a HeLa-specific Cytotoxic molecule that downregulates HPV-mediated signaling pathways via oxidative damage
- 이상희; 백수연; 조완상; 홍성렬; 이시형; 김희준; 박한검; 정진주; 신영기; 박승범
- Issue Date
- Organic & biomolecular chemistry
- VOL 17, NO 31-7397
- Selective bioactive compounds have emerged as major players in chemical biology for their potential in disrupting diverse biological pathways with minimal adverse effects. Using phenotypic screening, we identified an anti-cancer agent, SB2001, with a highly specific cytotoxicity toward HeLa human cervical cancer cells. The subsequent mechanistic study revealed that SB2001 induced apoptotic cell death through restoring p53 function and suppressed the human papillomavirus (HPV)-mediated oncoprotein signaling pathway via oxidative damage in HeLa cells. SB2001 also selectively induced HeLa-specific tumor regression without any adverse effects in an in vivo tumor xenograft model, demonstrating its potential as a promising chemical probe.
- Appears in Collections:
- KIST Publication > Article
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.