Uniaxially crumpled graphene as a platform for guided myotube formation

Title
Uniaxially crumpled graphene as a platform for guided myotube formation
Authors
김홍남Junghoon KimJuyoung LeemPilgyu KangJonghyun ChoiMd Farhadul HaqueDaeshik KangSungWoo Nam
Issue Date
2019-11
Publisher
Microsystems & Nanoengineering
Citation
VOL 5-53-10
Abstract
Graphene, owing to its inherent chemical inertness, biocompatibility, and mechanical flexibility, has great potential in guiding cell behaviors such as adhesion and differentiation. However, due to the two-dimensional (2D) nature of graphene, the microfabrication of graphene into micro/nanoscale patterns has been widely adopted for guiding cellular assembly. In this study, we report crumpled graphene, i.e., monolithically defined graphene with a nanoscale wavy surface texture, as a tissue engineering platform that can efficiently promote aligned C2C12 mouse myoblast cell differentiation. We imparted out-of-plane, nanoscale crumpled morphologies to flat graphene via compressive straininduced deformation. When C2C12 mouse myoblast cells were seeded on the uniaxially crumpled graphene, not only were the alignment and elongation promoted at a single-cell level but also the differentiation and maturation of myotubes were enhanced compared to that on flat graphene. These results demonstrate the utility of the crumpled graphene platform for tissue engineering and regenerative medicine for skeletal muscle tissues.
URI
http://pubs.kist.re.kr/handle/201004/70244
ISSN
2055-7434
Appears in Collections:
KIST Publication > Article
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