A new-infrared probe targeting mitochondria via regulation of molecular hydrophobicity

Title
A new-infrared probe targeting mitochondria via regulation of molecular hydrophobicity
Authors
이상희추연정성준노준기전경민준식김종현김욱김은하
Issue Date
2019-01
Publisher
Bioconjugate chemistry
Citation
VOL 30-217
Abstract
Herein, we developed a near-infrared (NIR) fluorescent probe for mitochondrial staining based on the NIR fluorochrome, silicon-rhodamine. The hydrophobicity of the fluorescent core was systematically modified by conjugation with 10 different commercial amines. The resulting fluorescent compounds exhibited similar photophysical properties but diverse hydrophobicity. We identified the optimal level of hydrophobicity associated with high mitochondrial targeting efficiency. In particular, the SiR-Mito 8 probe provided excellent mitochondrial staining and successfully differentiated the live Hep3B cancer cells from normal L02 cells in vitro.
URI
http://pubs.kist.re.kr/handle/201004/70247
ISSN
1043-1802
Appears in Collections:
KIST Publication > Article
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