L-DNA linear duplex: An efficient drug delivery carrier with a simple structure

Title
L-DNA linear duplex: An efficient drug delivery carrier with a simple structure
Authors
안대로유정헌김경란이아영
Issue Date
2019-06
Publisher
Journal of industrial and engineering chemistry
Citation
VOL 74-192
Abstract
Three dimensional DNA nanostructures are often limited in scalability due to low assembly yield at high concentrations, leaving themselves less suitable for industrial uses. To overcome this drawback, we here employed L-DNA duplex (L-ds) as a drug carrier. Due to its simple structure, L-ds can easily be prepared at micromolar concentrations without causing any considerable by-product, providing sufficient scalability for practical development. With sufficient cellular uptake efficiency in SCC7 cells and the tumor accumulation level in a SCC7-tumor xenograft mouse model, L-ds could well be utilized as a carrier for intracellular and tumor delivery of an anticancer agent, providing substantial cytotoxicity and inhibition of tumor growth, respectively.
URI
http://pubs.kist.re.kr/handle/201004/70259
ISSN
1226-086X
Appears in Collections:
KIST Publication > Article
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