Recent nanomedicine articles of outstanding interest: functional nanomaterials for Brain Research through Advancing Innovative Neurotechnologies initiative
- Recent nanomedicine articles of outstanding interest: functional nanomaterials for Brain Research through Advancing Innovative Neurotechnologies initiative
- 이준석; Ilya Ulasov; Elena A Rozhkova
- Issue Date
- VOL 11, NO 1-7
- Alzheimer's disease (AD) is the most common progressive neurodegenerative disease, affecting one in nine people over the age of 65 years . Despite huge personal and economic costs, development of efficacious treatments for AD is being held back by the lack of powerful diagnostic methods. Neurotoxic amyloid β oligomers (AβOs) are considered appropriate biomarkers for AD because AβOs appear early in the brain of patients with AD as main initiators of synapse failure . Therefore, an AβO-directed imaging diagnostic would provide molecule-targeted contrast for localization of early AβO accumulation in AD. Recently, Viola et al. reported a biocompatible, strong T2 contrast nanoprobe for MRI of AD-related AβOs . They selected an Fe3O4 magnetic nanostructure (MNS) and a monoclonal NU4 antibody as a T2 contrast platform and a recognizer of AβOs, respectively. Twelve to sixteen nanometer MNSs were synthesized by thermal decomposition of an iron-oleate complex and stabilized by nitro-dopamine as the surface anchor group and polyethylene glycol as a spacer. The NU4-conjugated MNS retained the high affinity and specificity of the parent antibody allowing for quick reaching toxic AβOs oligomers in vivo. AβO-targeted MNSs were delivered by intranasal administration and crossed the blood– brain barrier (BBB) to reach AβOs in the brain of 5XFAD mice. The MRI probe detected AD-causing AβOs in the mouse model within 4 h after administration and showed significant clearance from the brain within 96 h after administration. The development of nanomaterials targeting AβOs has diagnostic potential for early-stage AD.
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