Photoexcited Porphyrins as a Strong Suppressor of β­Amyloid Aggregation and Synaptic Toxicity

Title
Photoexcited Porphyrins as a Strong Suppressor of β­Amyloid Aggregation and Synaptic Toxicity
Authors
이준석이성수서윤석김애경권오유유권박찬범이병일
Issue Date
2015-09
Publisher
Angewandte Chemie international edition
Citation
VOL 54-11476
Abstract
The abnormal assembly of b-amyloid (Ab) peptides into neurotoxic, b-sheet-rich amyloid aggregates is a major pathological hallmark of AlzheimerÏ s disease (AD). Lightinduced photosensitizing molecules can regulate Ab amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso-tetra(4-sulfonatophenyl) porphyrin (TPPS with M=2H+, Zn2+, Cu2+, Mn2+) successfully inhibits Ab aggregation in vitro. Furthermore, Ab toxicity was relieved in the photoexcited-TPPStreated Drosophila AD model. TPPS suppresses neural cell death, synaptic toxicity, and behavioral defects in the Drosophila AD model under blue light illumination. Behavioral phenotypes, including larval locomotion defect and short lifespan caused by Ab overexpression, were also rescued by blue light-excited TPPS.
URI
http://pubs.kist.re.kr/handle/201004/70325
ISSN
1433-7851
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE