Photoexcited Porphyrins as a Strong Suppressor of βAmyloid Aggregation and Synaptic Toxicity
- Photoexcited Porphyrins as a Strong Suppressor of βAmyloid Aggregation and Synaptic Toxicity
- 이준석; 이성수; 서윤석; 김애경; 권오유; 유권; 박찬범; 이병일
- Issue Date
- Angewandte Chemie international edition
- VOL 54-11476
- The abnormal assembly of b-amyloid (Ab) peptides into neurotoxic, b-sheet-rich amyloid aggregates is a major pathological hallmark of AlzheimerÏ s disease (AD). Lightinduced photosensitizing molecules can regulate Ab amyloidogenesis. Multiple photochemical analyses using circular dichroism, atomic force microscopy, dot blot, and native gel electrophoresis verified that photoactivated meso-tetra(4-sulfonatophenyl) porphyrin (TPPS with M=2H+, Zn2+, Cu2+, Mn2+) successfully inhibits Ab aggregation in vitro. Furthermore, Ab toxicity was relieved in the photoexcited-TPPStreated Drosophila AD model. TPPS suppresses neural cell death, synaptic toxicity, and behavioral defects in the Drosophila AD model under blue light illumination. Behavioral phenotypes, including larval locomotion defect and short lifespan caused by Ab overexpression, were also rescued by blue light-excited TPPS.
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