Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers

Title
Preparation of Degradable Polymeric Nanoparticles with Various Sizes and Surface Charges from Polycarbonate Block Copolymers
Authors
조상호허규성Karen L. Wooley
Issue Date
2019-11
Publisher
Macromolecular research
Citation
VOL 27, NO 11-1178
Abstract
ABA-type polycarbonate block copolymers with pendant vinyl ether and benzyl functionalities were synthesized by sequential ring-opening polymerization of functional cyclic carbonate monomers using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an organobase catalyst. The vinyl ether moieties on the resulting block copolymers were readily conjugated with 3-mercaptopropionic acid, cysteamine hydrochloride, and L-cysteine hydrochloride monohydrate through thiol-ene “click” reactions, yielding anionic, cationic, and zwitterionic self-assembled nanoparticles, respectively, in corresponding buffers. The effect of pH on the size and surface charge of nanoparticles were examined.
URI
http://pubs.kist.re.kr/handle/201004/70356
ISSN
1598-5032
Appears in Collections:
KIST Publication > Article
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