Synthesis of alpha-(4-Oxazolyl)amino Esters via Bronsted Acid Catalyzed Tandem Reaction

Title
Synthesis of alpha-(4-Oxazolyl)amino Esters via Bronsted Acid Catalyzed Tandem Reaction
Authors
이안수Seohee OhHyunwoo Kim
Issue Date
2018-06
Publisher
Organic letters
Citation
VOL 20, NO 11-3322
Abstract
A one-step, Bronsted acid catalyzed tandem reaction for the synthesis of alpha-(4-oxazolyl)amino esters was developed. 4-Nitrobenzenesulfonic acid was found to be an efficient catalyst for the coupling of ethyl 2-oxobut-3-ynoates with amides to provide various a-(4-oxazolyl)amino esters. The experimental and X-ray crystallographic data suggest that a series of bond-forming reactions including imine formation, intermolecular Michael addition, and intramolecular Michael addition are functionalities.
URI
http://pubs.kist.re.kr/handle/201004/70412
ISSN
1523-7060
Appears in Collections:
KIST Publication > Article
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