An Enantioselective Cross-Dehydrogenative Coupling Catalysis Approach to Substituted Tetrahydropyrans

Title
An Enantioselective Cross-Dehydrogenative Coupling Catalysis Approach to Substituted Tetrahydropyrans
Authors
이안수Rick C. BetoriErika A. CraneKarl A. Scheidt
Issue Date
2018-05
Publisher
Journal of the American Chemical Society
Citation
VOL 140, NO 20-6216
Abstract
An enantioselective cross-dehydrogenative coupling (CDC) reaction to access tetrahydropyrans has been developed. This process combines in situ Lewis acid activation of a nucleophile in concert with the oxidative formation of a transient oxocarbenium electrophile, leading to a productive and highly enantioselective CDC. These advances represent one of the first successful applications of CDC for the enantioselective couplings of unfunctionalized ethers. This system provides efficient access to valuable tetrahydropyran motifs found in many natural products and bioactive small molecules.
URI
http://pubs.kist.re.kr/handle/201004/70429
ISSN
0002-7863
Appears in Collections:
KIST Publication > Article
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