Theacrine attenuates epithelial mesenchymal transition in human breast cancer MDA-MB-231 cells

Title
Theacrine attenuates epithelial mesenchymal transition in human breast cancer MDA-MB-231 cells
Authors
정상훈양민희Jeong-Hyeon KoSeung Ho BaekDongwoo NamKwang Seok Ahn
Keywords
breast cancer; EMT; metastasis; TGF-b; theacrine
Issue Date
2019-07
Publisher
Phytotherapy research : PTR
Citation
VOL 33, NO 7-1942
Abstract
Theacrine, a purine alkaloid structurally similar to caffeine, has recently become of interest as a potential therapeutic compound. Here, we investigated the antimetastatic potential of theacrine on human breast cancer MDA‐ MB‐ 231 cells. We observed that theacrine can reverse epithelial‐ to‐ mesenchymal transition (EMT), which resulted in a decrease in the levels of mesenchymal markers (Fibronectin, Vimentin, N‐ cadherin, Twist, and Snail) and an increase in the levels of epithelial markers (Occludin and E‐ cadherin) in the cells. Additionally, theacrine attenuates TGF‐ β‐ induced EMT, cell adhesion, migration, and invasion in MDA‐ 231 cells. Overall, our results suggest that theacrine may inhibit the breast cancer cell metastasis by reversing the EMT process.
URI
http://pubs.kist.re.kr/handle/201004/70522
ISSN
0951-418X
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KIST Publication > Article
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