Theacrine attenuates epithelial mesenchymal transition in human breast cancer MDA-MB-231 cells
- Theacrine attenuates epithelial mesenchymal transition in human breast cancer MDA-MB-231 cells
- 정상훈; 양민희; Jeong-Hyeon Ko; Seung Ho Baek; Dongwoo Nam; Kwang Seok Ahn
- breast cancer; EMT; metastasis; TGF-b; theacrine
- Issue Date
- Phytotherapy research : PTR
- VOL 33, NO 7-1942
- Theacrine, a purine alkaloid structurally similar to caffeine, has recently become of interest as a potential therapeutic compound. Here, we investigated the antimetastatic potential of theacrine on human breast cancer MDA‐ MB‐ 231 cells. We observed that theacrine can reverse epithelial‐ to‐ mesenchymal transition (EMT), which resulted in a decrease in the levels of mesenchymal markers (Fibronectin, Vimentin, N‐ cadherin, Twist, and Snail) and an increase in the levels of epithelial markers (Occludin and E‐ cadherin) in the cells. Additionally, theacrine attenuates TGF‐ β‐ induced EMT, cell adhesion, migration, and invasion in MDA‐ 231 cells. Overall, our results suggest that theacrine may inhibit the breast cancer cell metastasis by reversing the EMT process.
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