Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade

Title
Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
Authors
정상훈양민희Jong Hyun LeeJeong-Hyeon KoGautam SethiKwang Seok Ahn
Keywords
brassinin; EMT; lung carcinoma; PI3K/Akt/mTOR
Issue Date
2019-04
Publisher
Molecules
Citation
VOL 24, NO 8-1584-13
Abstract
The epithelial– mesenchymal transition (EMT) is a phenomenon that facilitates epithelial cells to acquire invasive potential to induce the initiation the metastatic spread of tumor cells. Here, we determined if brassinin (BSN) can a ect the EMT process and deciphered its anti-cancer e ects. BSN attenuated the levels of EMT linked genes and suppressed transforming growth factor beta (TGF- )-mediated regulation of diverse mesenchymal markers. Additionally, BSN did increase the expression of various epithelial marker proteins in lung cancer cells. TGF- -induced morphological changes and induction of invasive ability of tumor cells was also found to be abrogated by BSN treatment. Finally, BSN not only suppressed constitutive, but also inducible phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) phosphorylation in tumor cells.
URI
http://pubs.kist.re.kr/handle/201004/70523
ISSN
1420-3049
Appears in Collections:
KIST Publication > Article
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