Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
- Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
- 정상훈; 양민희; Jong Hyun Lee; Jeong-Hyeon Ko; Gautam Sethi; Kwang Seok Ahn
- brassinin; EMT; lung carcinoma; PI3K/Akt/mTOR
- Issue Date
- VOL 24, NO 8-1584-13
- The epithelial– mesenchymal transition (EMT) is a phenomenon that facilitates epithelial cells to acquire invasive potential to induce the initiation the metastatic spread of tumor cells. Here,
we determined if brassinin (BSN) can aect the EMT process and deciphered its anti-cancer eects. BSN attenuated the levels of EMT linked genes and suppressed transforming growth factor beta (TGF-)-mediated regulation of diverse mesenchymal markers. Additionally, BSN did increase the expression of various epithelial marker proteins in lung cancer cells. TGF--induced morphological changes and induction of invasive ability of tumor cells was also found to be abrogated by BSN treatment. Finally, BSN not only suppressed constitutive, but also inducible phosphoinositide-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) phosphorylation in tumor cells.
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