Genome-wide transcriptome analysis reveals intermittent fasting-induced metabolic rewiring in the liver

Title
Genome-wide transcriptome analysis reveals intermittent fasting-induced metabolic rewiring in the liver
Authors
김준기Gavin Yong-Quan NgSung-Wook KangAsfa Alli-ShaikSang-Ha BaikDong-Gyu JoM. Prakash HandeChristopher G. SobeyJayantha GunaratneDavid Yang-Wei FannThiruma V. Arumugam
Keywords
transcriptome; metabolism; liver; intermittent fasting; RNA sequencing
Issue Date
2019-09
Publisher
Dose-Response
Citation
VOL 17, NO 3-10
Abstract
Scope: Intermittent fasting (IF) has been extensively reported to promote improved energy homeostasis and metabolic switching. While IF may be a plausible strategy to ameliorate the epidemiological burden of disease in many societies, our understanding of the underlying molecular mechanisms behind such effects is still lacking. The present study has sought to investigate the relationship between IF and changes in gene expression. We focused on the liver, which is highly sensitive to metabolic changes due to energy status. Mice were randomly assigned to ad libitum feeding or IF for 16 hours per day or for 24 hours on alternate days for 3 months, after which genome-wide transcriptome analysis of the liver was performed using RNA sequencing. Our findings revealed that IF caused robust transcriptomic changes in the liver that led to a complex array of metabolic changes. We also observed that the IF regimen produced distinct profiles of transcriptomic changes, highlighting the significance of temporally different periods of energy restriction. Our results suggest that IF can regulate metabolism via transcriptomic mechanisms and provide insight into how genetic interactions within the liver might lead to the numerous metabolic benefits of IF.
URI
http://pubs.kist.re.kr/handle/201004/70541
ISSN
1559-3258
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE