Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles

Title
Supramolecular protection-mediated one-pot synthesis of cationic gold nanoparticles
Authors
이관희정영도이효진김성찬김민수바타크리쉬나 자나최후연진성은김기범이정민박명환유자형김채규
Issue Date
2020-01
Publisher
Journal of industrial and engineering chemistry
Citation
VOL 81-308
Abstract
Despite the extended use of cationic gold nanoparticles (AuNPs) in biomedical applications, direct one-pot synthesis of AuNPs with tunable size in aqueous media is limited due to the deleterious electrostatic attraction between AuCl4-anions and positively charged ligands. This paper describes the one-pot synthesis of cationic gold nanoparticles with size tunability based on host-guest chemistry. As the host molecule, cucurbit[7]uril inhibits self-aggregation in aqueous solution by threading positively charged guest ligands, which provides a shielding effect on the ligands. Reduction of the mixtures by directly adding NaBH4 generates cationic AuNPs with narrow size distributions. Furthermore, their potential in biomedical applications is demonstrated by siRNA transfection experiments. This approach relying on supramolecular-mediated interactions may provide new insights into organic/inorganic reactions that involve electrostatic disturbance.
URI
http://pubs.kist.re.kr/handle/201004/70564
ISSN
1226-086X
Appears in Collections:
KIST Publication > Article
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