Ordered assemblies of Fe3O4 and a donor-acceptor-type conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects
- Ordered assemblies of Fe3O4 and a donor-acceptor-type conjugated polymer in nanoparticles for enhanced photoacoustic and magnetic effects
- 김세훈; Thi-Thuy Duong Pham; 서영훈; 이다빈; 노주란; 채정완; 강은아; 박재홍; 신태주; 박주현
- Issue Date
- VOL 161-213
- We report that the ordered structure in the assemblies of iron oxide nanoparticles in conjugated polymer nanoparticles is the key to achieve better properties to realize multimodal theranostic agents for magnetic resonance and photoacoustic imaging. Hybrid nanoparticles of a conjugated polymer (PCPDTBT), a phospholipid (D8PE) with a primary amine polar head, and iron oxide (Fe3O4) nanoparticles were prepared by a phase-separated film shattering process by varying the iron oxide concentration while maintaining a fixed mixing ratio of PCPDTBT and D8PE. Notably, the hybrid nanoparticles assembled at a molar mixing ratio of 1:1:0.8 (PCPDTBT/D8PE/Fe3O4) exhibited the shortest transversal relaxation time, T2, and a photoacoustic signal 22 times higher than that obtained at the 1:1:0 mixing ratio. Structural analysis by X-ray diffraction together with the measurements of energy transfer by transient absorption spectroscopy confirmed that the structural ordering of these hybrid nanoparticles was responsible for their enhanced photoacoustic and magnetic properties.
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