Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice

Title
Roseburia spp. Abundance Associates with Alcohol Consumption in Humans and Its Administration Ameliorates Alcoholic Fatty Liver in Mice
Authors
차광현서보람전경찬문성현이기욱김운기정혜인임미영강원대권미나성주헌김원박주홍고광표
Keywords
microbiome; alcohol liver diseases; roseburia; fat liver diseases; hepatitis; occludin; liver steatosis; leaky gut
Issue Date
2020-01
Publisher
Cell host & microbe.
Citation
VOL 27, NO 1-40
Abstract
Although a link between the gut microbiota and alcohol-related liver diseases (ALDs) has previously been suggested, the causative effects of specific taxa and their functions have not been fully investigated to date. Here, we analyze the gut microbiota of 410 fecal samples from 212 Korean twins by using the Alcohol Use Disorders Identification Test (AUDIT) scales to adjust for host genetics. This analysis revealed a strong association between low AUDIT scores and the abundance of the butyrate-producing genus Roseburia. When Roseburia spp. are administered to ALD murine models, both hepatic steatosis and inflammation significantly improve regardless of bacterial viability. Specifically, the flagellin of R. intestinalis, possibly through Toll-like receptor 5 (TLR5) recognition, recovers gut barrier integrity through upregulation of the tight junction protein Occludin and helps to restore the gut microbiota through elevated expression of IL-22 and REG3 gamma. Our study demonstrates that Roseburia spp. improve the gut ecosystem and prevent leaky gut, leading to ameliorated ALD
URI
http://pubs.kist.re.kr/handle/201004/70885
ISSN
1931-3128
Appears in Collections:
KIST Publication > Article
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