Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
- Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
- 김수남; 이소연; 박노준; 제갈종환; 조범근; 최상호; 이상우; Md Salah Uddin; 양민혜
- Wikstroemia indica; 2,4-dinitrochlorobenzene; atopic dermatitis; transepidermal water loss; interleukin
- Issue Date
- VOL 12, NO 1, E173
- Wikstroemia indica (L.) C.A.Mey. is used in traditional Chinese medicine to treat inflammatory
diseases such as arthritis and bronchitis. In this study, we aimed to investigate the eects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at aW. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.
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