Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract

Title
Suppression of DNCB-Induced Atopic Skin Lesions in Mice by Wikstroemia indica Extract
Authors
김수남이소연박노준제갈종환조범근최상호이상우Md Salah Uddin양민혜
Keywords
Wikstroemia indica; 2,4-dinitrochlorobenzene; atopic dermatitis; transepidermal water loss; interleukin
Issue Date
2020-01
Publisher
Nutrients
Citation
VOL 12, NO 1, E173
Abstract
Wikstroemia indica (L.) C.A.Mey. is used in traditional Chinese medicine to treat inflammatory diseases such as arthritis and bronchitis. In this study, we aimed to investigate the e ects of an ethanolic extract of W. indica on cutaneous inflammation in mice with 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD). Dermal administration of W. indica ethanolic extract to DNCB-sensitized hairless mice with dermatitis, for two weeks, reduced erythema, scaling, and edema. Skin hydration was improved and transepidermal water loss was reduced at aW. indica concentration of 1%. Furthermore, W. indica also significantly reduced serum IgE and IL-4 concentrations in our mouse model. These results suggest that W. indica has potential as a topical treatment for AD and as an adjunctive agent to control AD.
URI
http://pubs.kist.re.kr/handle/201004/70974
ISSN
2072-6643
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KIST Publication > Article
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