Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin

Title
Identification of a Novel Oxadiazole Inhibitor of Mammalian Target of Rapamycin
Authors
허우영임선우김의정이효민
Keywords
Mammalian target of rapamycin; Screening; mTOR; Inhibitor; 2,3-Dihydro-1,3,4-oxadiazole
Issue Date
2020-03
Publisher
Bulletin of the Korean Chemical Society
Citation
VOL 41, NO 3-303
Abstract
We performed a biochemical screen against mTOR using in‐ house small molecule library. Two novel, structurally distinct hits were identified. Among them, a novel oxadiazole scaffold compound (2) suppressed the phosphorylation of both S6K1 and Akt1 in HeLa cells. Docking study suggested that 2 is ATP‐ competitive and shows a pi‐ pi interaction with Trp2239 and hydrogen bonds with Trp2239 and Thr2245. Through derivatization, a slightly more potent analogue (2a) was identified with IC50 of 9.6 μM. Our study provides a starting point for discovery of novel potent mTOR inhibitors.
URI
http://pubs.kist.re.kr/handle/201004/70980
ISSN
0253-2964
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE