Fabrication of 3D plotted scaffold with microporous strands for bone tissue engineering

Title
Fabrication of 3D plotted scaffold with microporous strands for bone tissue engineering
Authors
김상헌오승자Ji Min SeokThanavel RajangamJae Eun JeongSinyoung CheongSang Min JooHeungsoo ShinSu A Park
Issue Date
2020-02
Publisher
Journal of materials chemistry. B, Materials for biology and medicine
Citation
VOL 8, NO 5-960
Abstract
Scaffold porosity has played a key role in bone tissue engineering aimed at effective tissue regeneration, by promoting cell attachment, proliferation, and osteogenic differentiation for new bone formation. Three-dimensional plotting systems (3DPSs) have been widely used to introduce porosity to the scaffold; however, introducing certain features in the scaffold strands that improve bone tissue regeneration remains a challenge. In this work, we fabricated bone tissue scaffolds with macro- and microporous structural features using a 3DPS and non-solvent-induced phase separation method. This approach allowed both macro- and micropores to be created in the scaffold strands. The surface morphology and mechanical and degradation properties of the perforated scaffolds were characterized carefully. Human marrow stromal cells were cultured on the scaffolds and then analyzed in vitro to assess scaffold bio-function. The highly porous scaffold exhibited mechanical properties similar to those of cancellous bone. Cell attachment, proliferation, and differentiation were significantly higher in porous scaffold compared to its nonporous counterpart. These results suggest that highly porous scaffolds have tremendous potential as a bone tissue regeneration platform.
URI
http://pubs.kist.re.kr/handle/201004/70986
ISSN
2050-750X
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KIST Publication > Article
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