Real-time label-free quantitative monitoring of biomolecules without surface binding by floating-gate complementary metal-oxide semiconductor sensor array integrated with readout circuitry

Title
Real-time label-free quantitative monitoring of biomolecules without surface binding by floating-gate complementary metal-oxide semiconductor sensor array integrated with readout circuitry
Authors
임매순김성진유규태심저영정원석고한승김이섭윤의식
Issue Date
2007-11
Publisher
Applied physics letters
Citation
VOL 91, NO 20, 203903
Abstract
We report a label-free field-effect sensing array integrated with complementary metal-oxide semiconductor CMOS readout circuitry to detect the surface potential determined by the negative charge in DNA molecules. For real-time DNA quantification, we have demonstrated the measurements of DNA molecules without immobilizing them on the sensing surface which is composed of an array of floating-gate CMOS transistors. This nonimmobilizing technique allows the continuous monitoring of the amount of charged molecules by injecting DNA solutions sequentially. We have carried out the real-time quantitative measurement of 19 bp oligonucleotides and analyzed its sensitivity as a function of pH in buffer solutions.
URI
http://pubs.kist.re.kr/handle/201004/71043
ISSN
0003-6951
Appears in Collections:
KIST Publication > Article
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