Microphysiological systems for recapitulating physiology and function of blood-brain barrier

Title
Microphysiological systems for recapitulating physiology and function of blood-brain barrier
Authors
최낙원김홍남서수영김휘은성종환이강원
Issue Date
2020-02
Publisher
Biomaterials
Citation
VOL 232-119732
Abstract
Thiostannate ammonium chalcogenide aerogel (TAC) is synthesized through a unique self-crosslinking polymerization reaction between tetrahedral thiostannate dimer clusters ([Sn2S6]4− ) and various ammonium ligands (NR4+). TAC is a unique and rare chalcogenide aerogel (so called “chalcogel”) stabilized without using a cationic transition metal center. In-depth and synergistic structural analyses reveal that after the self-condensation reaction, the thiostannate clusters are stabilized into a three-dimensional solid network with the support of an ammonium spacer. Consequently, thiostannate coordination is successfully transformed from tetrahedral to a distorted trigonal bipyramidal geometry, yielding a [Sn3S7]2− cluster-based porous chalcogenide network. This organic/inorganic heterostructure has a large specific surface area (158– 363 m2 g− 1), macroscopically random orientation of pores, soft basicity, controllable hosting ammonium ligand, and rapid mass transport through multiscale channels. These characteristics enable remarkable radionuclide control functionality such as large Cs+ adsorption capacity (141– 220 mg g− 1), high selectivity towards cations with intermediate chemical hardness (e.g., Cs+), structural integrity over a wide pH range (2– 8), and rapid ion uptake (50% in 30 min and complete equilibrium within 3 h). This study demonstrates that the self-crosslinking mechanism of chalcometallate clusters can be utilized as a diverse platform to synthesize a broad range of chalcogenide heterostructures with desirable functionalities.
URI
http://pubs.kist.re.kr/handle/201004/71065
ISSN
0142-9612
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