Recycling Endosomes Supply AMPA Receptors for LTP

Title
Recycling Endosomes Supply AMPA Receptors for LTP
Authors
박미경Esther C. PenickJeffrey G. EdwardsJulie A. KauerMichael D. Ehlers
Issue Date
2004-09
Publisher
Science
Citation
VOL 305-1975
Abstract
Long-term potentiation (LTP) of synaptic strength, the most established cellular model of information storage in the brain, is expressed by an increase in the number of postsynaptic AMPA receptors. However, the source of AMPA receptors mobilized during LTP is unknown. We report that AMPA receptors are transported from recycling endosomes to the plasma membrane for LTP. Stimuli that triggered LTP promoted not only AMPA receptor insertion but also generalized recycling of cargo and membrane from endocytic compartments. Thus, recycling endosomes supply AMPA receptors for LTP and provide a mechanistic link between synaptic potentiation and membrane remodeling during synapse modification.
URI
http://pubs.kist.re.kr/handle/201004/71072
ISSN
0036-8075
Appears in Collections:
KIST Publication > Article
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