Spatial properties of network-mediated response of retinal ganglion cells to electric stimulation

Title
Spatial properties of network-mediated response of retinal ganglion cells to electric stimulation
Authors
임매순Shelley I. Fried
Issue Date
2015-04
Publisher
7th Annual International IEEE EMBS Conference on Neural Engineering
Abstract
Retinal prosthetics consistently demonstrate the ability to restore limited visual perception to those blinded from outer retinal degenerative diseases. However, the performance of retinal implants is highly inconsistent and high-density arrays have proven only marginally better than much sparser ones suggesting that improving the overall quality of elicited vision may require more than just a high density electrode array. Existing devices are also implanted subretinally and epiretinally raising the possibility that electrode location also contributes to percept quality. Here, we compared the responses to stimulation from subretinal and epiretinal electrodes in the same cell. Use of a 4×4 subretinal electrode array allowed us to also compare responses to different numbers of electrodes activated simultaneously. Surprisingly, responses showed minimal dependence of both the electrode position (epiretinal vs. subretinal) as well as on electrode size (one vs. up to nine electrodes). However, when charge density considerations are implemented, such as those that are necessary during clinical use, the responses arising from smaller electrodes were less effective. This finding may help to explain the inconsistency between theoretical visual acuity and achievement in clinical testing with the high density implanted arrays.
URI
http://pubs.kist.re.kr/handle/201004/71087
ISSN
-
Appears in Collections:
KIST Publication > Conference Paper
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