Copper-64-Alloyed Gold Nanoparticles for Cancer Imaging: Improved Radiolabel Stability and Diagnostic Accuracy

Title
Copper-64-Alloyed Gold Nanoparticles for Cancer Imaging: Improved Radiolabel Stability and Diagnostic Accuracy
Authors
조상호Yongfeng ZhaoDeborah SultanLisa DeteringGuorong SunRichard PierceKaren L. WooleyYongjian Liu
Issue Date
2014-01
Publisher
Angewandte Chemie international edition
Citation
VOL 53, NO 1-159
Abstract
Gold nanoparticles, especially positron-emitter- labeled gold nanostructures, have gained steadily increasing attention in biomedical applications. Of the radionuclides used for nanoparticle positron emission tomography imaging, radiometals such as Cu-64 have been widely employed. Currently, radiolabeling through macrocyclic chelators is the most commonly used strategy. However, the radiolabel stability may be a limiting factor for further translational research. We report the integration of Cu-64 into the structures of gold nanoparticles. With this approach, the specific radioactivity of the alloyed gold nanoparticles could be freely and precisely controlled by the addition of the precursor (CuCl2)-Cu-64 to afford sensitive detection. The direct incorporation of Cu-64 into the lattice of the gold nanoparticle structure ensured the radiolabel stability for accurate localization invivo. The superior pharmacokinetic and positron emission tomography imaging capabilities demonstrate high passive tumor targeting and contrast ratios in a mouse breast cancer model, as well as the great potential of this unique alloyed nanostructure for preclinical and translational imaging.
URI
http://pubs.kist.re.kr/handle/201004/71169
ISSN
1433-7851
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE