Supramolecular Nanofibrillar Thermoreversible Hydrogel for Growth and Release of Cancer Spheroids

Title
Supramolecular Nanofibrillar Thermoreversible Hydrogel for Growth and Release of Cancer Spheroids
Authors
조상호Yunfeng LiNancy KhuuAlbert GevorkianSharon SarjinskyHeloise Therien-AubinYihe WangEugenia Kumacheva
Issue Date
2017-05
Publisher
Angewandte Chemie international edition
Citation
VOL 56, NO 22-6087
Abstract
Growth of three-dimensional cancer spheroids (CSs) in man-made hydrogels mimicking natural extracellular matrix is an important and challenging task. Herein, we report on a supramolecular temperature-responsive hydrogel designed for the growth and subsequent release of CSs. A filamentous hydrogel was formed at 37 degrees C from an aqueous suspension of cellulose nanocrystals surface-functionalized with temperature-responsive polymer molecules. The encapsulation of cells in the hydrogel enabled effective growth of CSs with dimensions determined by the concentration of cellulose nanocrystals in the hydrogel. On demand release of CSs without loss of cell viability and spheroid integrity was achieved upon hydrogel cooling. The tumorigenic properties of the released CSs were examined by encapsulating and regrowing them in fibrin hydrogel. The results in this work can be used in fundamental cancer research and in cancer drug screening.
URI
http://pubs.kist.re.kr/handle/201004/71178
ISSN
1433-7851
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KIST Publication > Article
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