Microfluidic assembly of liposomes dual-loaded with catechin and curcumin for enhancing bioavailability

Title
Microfluidic assembly of liposomes dual-loaded with catechin and curcumin for enhancing bioavailability
Authors
판철호김진철홍시락홍성철박경민양승훈유형석백현동장판식
Issue Date
2020-06
Publisher
Colloids and surfaces. A, Physicochemical and engineering aspects
Citation
VOL 594, 1246720
Abstract
0.05). These results demonstrate the potential of dual encapsulation of bioactive compounds for enhancing bioavailability and advance the dual-loading technique using microfluidic assembly in the field of liposomal encapsulation of drugs or functional compounds.; Curcumin and catechin have inhibitory effects on tumor cell growth. However, the biological activity of curcumin is limited by its low solubility in water. Liposomes are useful carriers of bioactive compounds given their structural similarity to the cellular membrane, but conventional methods for dual-loading liposome preparation are limited to scaled-up applications. Herein, we first applied a microfluidic technique to produce dual-loaded liposomes containing curcumin and catechin by using dipalmitoylphosphatidylcholine as a building block. The dual-loading liposomes were monodispersed (PdI&#8239; <&#8239; 0.2) spherical vesicles, less than 200&#8239; nm in size and the encapsulation efficiencies of curcumin and catechin on the liposome were 100 % and 16.77 %, respectively. Although all anti-proliferation activities were dose-dependently increased in colon cancer cells by catechin, curcumin, and liposomes, only the dual-loaded liposomes exhibited significantly higher inhibition activity (p&#8239
URI
http://pubs.kist.re.kr/handle/201004/71407
ISSN
0927-7757
Appears in Collections:
KIST Publication > Article
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE