Two-phase flow in microfluidic-chip design of hydrodynamic filtration for cell particle sorting

Title
Two-phase flow in microfluidic-chip design of hydrodynamic filtration for cell particle sorting
Authors
전명석윤규정현욱
Keywords
Cell sorting; Channel design; Hydrodynamic filtration; Microfluidic-chip; Two-phase flow
Issue Date
2020-06
Publisher
Electrophoresis
Citation
VOL 41-1010
Abstract
As one of the flow-based passive sorting, the hydrodynamic filtration using amicrofluidicchip has shown to effectively separate into different sizes of subpopulations from cell or particle suspensions. Itsmodel framework involving two-phase Newtonian or generalized Newtonian fluid (GNF) was developed, by performing the complete analysis of laminar flow and complicated networks of main and multiple branch channels. To predict rigorously what occurs in flow fields, we estimated pressure drop, velocity profile, and the ratio of the flow fraction at each branch point, in which the analytical model was validated with numerical flow simulations. As a model fluid of the GNF, polysaccharide solution based on Carreau type was examined. The objective parameters aiming practical channel design include the number of the branches and the length of narrow section of each branch for arbitrary conditions. The flow fraction and the number of branches are distinctly affected by the viscosity ratio between feed and side flows. As the side flow becomes more viscous, the flow fraction increases but the number of branches decreases, which enables a compact chip designed with fewer branches being operated under the same throughput. Hence, our rational design analysis indicates the significance of constitutive properties of each stream.
URI
http://pubs.kist.re.kr/handle/201004/71441
ISSN
0173-0835
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