Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications

Title
Applications of Converged Various Forces for Detection of Biomolecules and Novelty of Dielectrophoretic Force in the Applications
Authors
이병철Seungjun LeeSeong Min RohEunji LeeYejin ParkYoungeun KwonHye Jin KimJinsik Kim
Keywords
biomolecule separation; dielectrophoresis; electrophoresis; acoustophoretic; electroosmotic flow force; magnetophoretic force; electrokinetic force; hydrodynamic force; optical trapping force
Issue Date
2020-06
Publisher
Sensors
Citation
VOL 20, NO 11-18
Abstract
Since separation of target biomolecules is a crucial step for highly sensitive and selective detection of biomolecules, hence, various technologies have been applied to separate biomolecules, such as deoxyribonucleic acid (DNA), protein, exosome, virus, etc. Among the various technologies, dielectrophoresis(DEP)hasthesignifi cantadvantagethattheforcecanprovidetwodiff erenttypesof forces, attractive and repulsive DEP force, through simple adjustment in frequency or structure of microfl uidic chips. Therefore, in this review, we focused on separation technologies based on DEP force and classifi ed various separation technologies. First, the importance of biomolecules, general separationmethodsandvariousforcesincludingDEP,electrophoresis(EP),electrothermalfl ow(ETF), electroosmosis (EO), magnetophoresis, acoustophoresis (ACP), hydrodynamic, etc., was described. Then, separating technologies applying only a single DEP force and dual force, moreover, applying other forces simultaneously with DEP force were categorized. In addition, advanced technologies applying more than two diff erent kinds of forces, namely complex force, were introduced. Overall, we critically reviewed the state-of-the-art of converged various forces for detection of biomolecules with novelty of DEP.
URI
http://pubs.kist.re.kr/handle/201004/71463
ISSN
1424-8220
Appears in Collections:
KIST Publication > Article
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