Biodegradable Magnesium Alloys Promote Angio­Osteogenesis to Enhance Bone Repair

Title
Biodegradable Magnesium Alloys Promote Angio­Osteogenesis to Enhance Bone Repair
Authors
석현광김유찬한형섭이경우전인동이강식Frank WitteDiego MantovaniSion Glyn-JonesJames R Edwards
Issue Date
2020-08
Publisher
Advanced science
Citation
VOL 7, NO 15, 2000800
Abstract
Biodegradable metallic materials represent a potential step-change technology that may revolutionize the treatment of broken bones. Implants made with biodegradable metals are significantly stronger than their polymer counterparts and fully biodegradable in vivo, removing the need for secondary surgery or long-term complications. Here, it is shown how clinically approved Mg alloy promotes improved bone repair using an integrated state of the art fetal mouse metatarsal assay coupled with in vivo preclinical studies, second harmonic generation, secretome array analysis, perfusion bioreactor, and high-resolution 3D confocal imaging of vasculature within skeletal tissue, to reveal a vascular-mediated pro-osteogenic mechanism controlling enhanced tissue regeneration. The optimized mechanical properties and corrosion rate of the Mg alloy lead to a controlled release of metallic Mg, Ca, and Zn ions at a rate that facilitates both angiogenesis and coupled osteogenesis for better bone healing, without causing adverse effects at the implantation site. The findings from this study support ongoing development and refinement of biodegradable metal systems to act as crucial portal technologies with significant potential to improve many clinical applications.
URI
http://pubs.kist.re.kr/handle/201004/71902
ISSN
2198-3844
Appears in Collections:
KIST Publication > Article
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