Calvatianone a sterol possessing a 6/5/6/5-fused ring system with a contracted tetrahydrofuran B-Ring, from the fruiting bodies of calvatia nipponica

Title
Calvatianone a sterol possessing a 6/5/6/5-fused ring system with a contracted tetrahydrofuran B-Ring, from the fruiting bodies of calvatia nipponica
Authors
김진철이슬아이다혜류림박현봉강기성김기현
Issue Date
2020-09
Publisher
Journal of natural products
Citation
VOL 83-2742
Abstract
Calvatia nipponica is an extremely rare mushroom with a limited number of studies on its chemical components and biological activities published. Here we report the isolation of a novel sterol, calvatianone (1), possessing a 6/5/6/5-fused ring system with a contracted tetrahydrofuran B-ring, and four known steroids (2– 5) from the fruiting bodies of C. nipponica. The structure of calvatianone including its absolute configuration was determined by NMR spectroscopic analyses, HR-ESIMS, gauge-including atomic orbital NMR chemical shift calculations, and ECD calculations. Ergosterol peroxide (3) and cyathisterol (4) suppressed the cell viability increase induced by 17β-estradiol in MCF-7 breast cancer cell lines, suggesting a possible approach for these compounds to serve as ERα antagonists.
URI
http://pubs.kist.re.kr/handle/201004/71936
ISSN
0163-3864
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KIST Publication > Article
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